P. White
2001
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Abstract
Mono-benzyl phosphate esters of Fmoc protected phosphoamino acids, Fmoc-Aaa(PO(OBzl)OH)-OH (Aaa = Ser, Thr, Tyr), are extremely valuable tools for the synthesis of phosphopeptides by Fmoc SPPS methods [1]. However, a recent report [2] has indicated that the use of standard activation methods with these derivatives can lead to poor yields. In this poster, the development of an optimized coupling protocol and its application in the synthesis of multiphosphorylated peptides is described.