Yin Jian-zhong
2010
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Journal
Technology & Development of Chemical Industry
Abstract
Methyl 2-amino-5-fluorobenzoate was synthesized through a series of reactions of nitrification,esterification and hydronation used 3-fluorobenzoic acid as raw material.By compared with different synthesis methods,an optimal synthesis route was present:3-fluorobenzoic acid reacted with mixed acid,then reacted with methanol.By reduction the target product was received with the yield of 81%.The structure of the product was affirmed by melting point,IR,NMR and GC-MS,and GC99%,LC98.5%.