Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

doi:10.4103/0974-2077.191657

Paper

Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

Published Jul 1, 2016 · Suruchi Garg

Journal of Cutaneous and Aesthetic Surgery

Q3 SJR score

55

Citations

1

Influential Citations

Full text Semantic Scholar

Abstract

Context: Platelet-rich plasma (PRP) therapy is finding importance in aesthetic medicine. Aim: The objective of this study was to study efficacy of PRP therapy in follicular unit extraction (FUE) hair transplant. Materials and Methods: It is a single-blind, prospective randomised study on 40 FUE hair transplant subjects, allocated in two groups (PRP and non-PRP) alternately. PRP was injected intra-operatively immediately after creating slits over the recipient area in PRP group; and normal saline in non-PRP group. Two groups were evaluated at 2, 4 and 8 weeks, 3 and 6 months of the procedure. Statistical Analysis: It was done using Chi-square test and test of significance was set as P < 0.05. Results: In PRP group, all subjects had >75% hair regrowth at 6 months, density of >75% grafts was noticed in 12 patients at 4 weeks meaning reduced fall of transplanted hair during catagen phase. New hair growth started at 8 weeks in 16 patients and redness over recipient area completely disappeared in 19 patients at 3 months of surgery and activity in dormant follicles as fine thread like hair was noticed besides the thick transplanted hair in all subjects. In non-PRP group, four patients had >75% hair regrowth at 6 months; none showed >75% graft density at 4 weeks, and 13 subjects showed dormant follicle activity at 4 months. The number of patients having lengthier hairs was significantly more in PRP group. Conclusion: Intra-operative PRP therapy is beneficial in giving faster density, reducing the catagen loss of transplanted hair, recovering the skin faster and activating dormant follicles in FUE transplant subjects.

RCT

Study Snapshot

Key takeawayIntra-operative PRP therapy improves hair density, reduces catagen loss, accelerates skin recovery, and activates dormant follicles in FUE hair transplant patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

Sign up to use Study Snapshot

References

Potential targets in the discovery of new hair growth promoters for androgenic alopecia

New hair growth promoters for androgenic alopecia should target multiple androgen receptors and growth-factor-producing genes, as single targeted agents may not be sufficient for effective treatment.

The Effect of Autologous Activated Platelet Rich Plasma (AA-PRP) Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

AA-PRP injections show potential in improving pattern hair loss by increasing hair growth, density, and keratinocyte proliferation in the treated scalp.

The effect of CD34+ cell‐containing autologous platelet‐rich plasma injection on pattern hair loss: a preliminary study

CD34+ cell-containing autologous platelet-rich plasma injections may have potential in treating pattern hair loss by promoting active hair growth and promoting dermal papilla cell proliferation.

Proteomic analysis of balding and non-balding mesenchyme-derived dermal papilla cells from androgenetic alopecia patients using on-line two-dimensional reversed phase-reversed phase LC-MS/MS.

This study identified 128 up-regulated and 12 down-regulated proteins in balding mesenchyme-derived dermal papilla cells, potentially aiding in understanding the pathogenesis of androgenetic alopecia.

Review of Factors Affecting the Growth and Survival of Follicular Grafts

Hair restoration surgeons should focus on fundamentals like hair care, hydration, temperature, time out of body, and gentle handling to improve follicular graft growth and survival.

Platelet-Rich Plasma: Support for Its Use in Wound Healing

Platelet-rich plasma (PRP) shows potential in wound healing and is safe, but more randomized controlled studies are needed to confirm its efficacy and guide future treatment for chronic diabetic foot ulceration.

The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

Platelet plasma growth factors significantly improve hair density and yield in male pattern baldness surgery, with potential for low cost-to-benefit ratio and less morbidity.

Androgenetic alopecia and current methods of treatment.

Topical minoxidil and finasteride are effective treatments for male baldness, while antiandrogens and topical minoxidil are effective for mild to moderate female alopecia.

Regulation of PDGF and PDGF receptor in cultured dermal papilla cells and follicular keratinocytes of the human hair follicle

Cultured follicular keratinocytes express both types of PDGF receptors, while dermal papilla cells only express PDGF receptor, highlighting the importance of PDGF in hair follicle development and vasculogenesis.

Citations