An Overview of the Biological Activity of Pyrrolo[3,4-c]pyridine Derivatives

doi:10.3390/ph14040354

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An Overview of the Biological Activity of Pyrrolo[3,4-c]pyridine Derivatives

Published Apr 1, 2021 · A. Wójcicka, A. Redzicka

Pharmaceuticals

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Abstract

Pyrrolo[3,4-c]pyridine is one of the six structural isomers of the bicyclic ring system containing a pyrrole moiety fused to a pyridine nucleus. The broad spectrum of pharmacological properties of pyrrolo[3,4-c]pyridine derivatives is the main reason for developing new compounds containing this scaffold. This review presents studies on the biological activity of pyrrolo[3,4-c]pyridines that have been reported in the scientific literature. Most of these derivatives have been studied as analgesic and sedative agents. Biological investigations have shown that pyrrolo[3,4-c]pyridines can be used to treat diseases of the nervous and immune systems. Their antidiabetic, antimycobacterial, antiviral, and antitumor activities also have been found.

Literature Review

Study Snapshot

Pyrrolo[3,4-c]pyridine derivatives show potential as analgesic, sedative agents, and treatments for nervous and immune system diseases, as well as antibacterial, antiviral, and antitumor properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

An Overview of the Biological Activity of Pyrrolo[3,4-c]pyridine Derivatives

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