A. Ghauch, A. Tuqan
Feb 15, 2012
Citations
3
Influential Citations
306
Citations
Quality indicators
Journal
Chemical Engineering Journal
Abstract
Abstract The oxidative removal of dissolved aqueous bisoprolol (BIS) fumarate, prescribed to treat hypertension, by thermally activated sodium persulfate (Na 2 S 2 O 8 ; SPS) was investigated in a phosphate buffer solution at pH 7.0 and different temperatures. The results showed that BIS disappearance was pseudo-first order for 1–4 half-lives and the resulting rate constants—observed from 40 to 70 °C—fit the Arrhenius equation, yielding apparent activation energy of 119.8 (±10.8) kJ mol −1 . The observed aqueous phase BIS degradation half-lives ranged from 1.9 (±0.1) to 93.7 (±6.3) min. The effect of various inorganic additives on maintaining high reaction stoichiometric efficiency (RSE) and SPS activation was studied. The results indicated that only HCO 3 − slightly affected BIS degradation rate although full degradation was noticed at 60 °C. A test on BIS spiked local commercial mineral water showed full degradation of BIS after 1 h of reaction. HPLC/MS analysis showed the presence of intermediate oxidized products. The high RSE obtained demonstrated that the use of thermally activated SPS is a suitable advanced oxidation process for the degradation of pharmaceutical compounds in water.