PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.

doi:10.1016/j.molcel.2018.05.009

Paper

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.

Published Jun 1, 2018 · Hyerim Yi, Joha Park, Minju Ha

Molecular cell

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152

Citations

15

Influential Citations

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Abstract

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Study Snapshot

PABP and the CCR4-NOT complex work together to promote mRNA deadenylation and prevent premature decay, revealing distinct functions of deadenylases and PABPC in mRNA regulation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.

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References

The Interplay between the RNA Decay and Translation Machinery in Eukaryotes.

RNA decay and protein synthesis play a crucial role in gene expression regulation in eukaryotic cells, with mRNA decay playing a key role in coordinating post-transcriptional regulation.

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Multiple PABPC1 molecules on poly(A) form a wormlike structure, which plays a crucial role in regulating mRNA translation and mRNA metabolism.

Short Poly(A) Tails are a Conserved Feature of Highly Expressed Genes

Short poly(A) tails are a conserved feature of well-expressed genes, suggesting that they are linked to translational efficiency and may serve protective and translational functions.

Antagonistic actions of two human Pan3 isoforms on global mRNA turnover

Two human Pan3 isoforms, Pan3S and Pan3L, play opposing roles in coordinating the two phases of deadenylation, affecting global mRNA stability and gene expression.

mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

TUT4 and TUT7 uridylate mRNA, shaping the maternal transcriptome during oogenesis, essential for oocyte maturation and fertility.

Citations

The ribosome as a platform to coordinate mRNA decay

The ribosome plays a central role in coordinating mRNA decay, facilitating both translation and mRNA stability regulation through factors like Ccr4-Not complex and canonical exonucleases.

The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT

The Legionella pneumophila effector PieF modulates host mRNA stability and expression by directly targeting the eukaryotic CCR4NOT complex, influencing mRNA metabolism across various eukaryotic cells.

Phosphorylation-dependent tuning of mRNA deadenylation rates

Phosphorylation-dependent multivalent interactions and phosphorylation are conserved strategies for regulating gene expression, allowing mRNA decay to be fine-tuned in response to cellular cues.

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

Specific arginine tRNAs in the P-site promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes, accelerating mRNA turnover in mammals.

Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

Human DCP1 plays a crucial role in mRNA decapping and has distinct functions in regulating specific mRNA targets and biological processes.