Palladium-catalyzed carbonylation of haloindoles: no need for protecting groups.

doi:10.1021/OL035988R

Paper

Palladium-catalyzed carbonylation of haloindoles: no need for protecting groups.

Published 2004 · Kamal Kumar, Alexander Zapf, Dirk Michalik

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70

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Abstract

[reaction: see text] For the first time, palladium-catalyzed carbonylations of unprotected bromoindoles have been performed successfully with different N- and O-nucleophiles. Various indole carboxylic acid derivatives are accessible in excellent yield. For example, aminocarbonylation of 4-, 5-, 6-, or 7-bromoindole with arylethylpiperazines provides a direct one-step synthesis for CNS active amphetamine derivatives.

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Palladium-catalyzed carbonylation of unprotected bromoindoles allows for excellent yields of various indole carboxylic acid derivatives, including CNS active amphetamine derivatives.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Palladium-catalyzed carbonylation of haloindoles: no need for protecting groups.

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