Paper
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti‐inflammatory agent
Published Jan 1, 2015 · F. Borrelli, B. Romano, S. Petrosino
British Journal of Pharmacology
Q1 SJR score
151
Citations
8
Influential Citations
Abstract
Palmitoylethanolamide (PEA) acts via several targets, including cannabinoid CB1 and CB2 receptors, transient receptor potential vanilloid type‐1 (TRPV1) ion channels, peroxisome proliferator‐activated receptor alpha (PPAR α) and orphan G protein‐coupled receptor 55 (GRR55), all involved in the control of intestinal inflammation. Here, we investigated the effect of PEA in a murine model of colitis.
Non-RCT
Animal Study
Highly CitedStudy Snapshot
Palmitoylethanolamide effectively reduces intestinal inflammation in a murine model of colitis, acting through multiple targets and pathways.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Citations
Lipid mediator palmitoylethanolamide (PEA) inhibits pathogenic T cell differentiation in vitro and in vivo.
PEA inhibits pathogenic T cell differentiation, potentially offering a new therapeutic option for inflammatory autoimmune and allergic diseases based on excessive T cell activity.
2024·0citations·Yasuhiro Soga et al.·Biochemical and biophysical research communications
Biochemical and biophysical research communications
The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases
PPARs play a diverse role in immune-mediated intestinal diseases, and synthetic PPAR ligands show promise for treating inflammation and fibrosis through modulation of activation and microbiota composition.
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Chronic PPARα/γ and CB2R agonist treatments attenuated visceral adipose tissue (VAT)-derived extracellular vesicle-related VAT and intestinal abnormalities in NASH mice.
Combined PPAR/ and CB2R agonist treatment reduces inflammation, fibrosis, and intestinal abnormalities in NASH mice, suggesting VAT-derived extracellular vesicles contribute to the disease.
2024·0citations·Chia-Chang Huang et al.·The American journal of pathology
The American journal of pathology
N-palmitoyl-d-glucosamine limits mucosal damage and VEGF-mediated angiogenesis by PPARα-dependent suppression of pAkt/mTOR/HIF1α pathway and increase in PEA levels in AOM/DSS colorectal carcinoma in mice.
mPGA shows potential as a nutritional intervention to counteract inflammation-related angiogenesis in colorectal carcinoma by suppressing the pAkt/mTOR/HIF1 pathway and increasing PEA levels.
2024·0citations·Irene Palenca et al.·Phytotherapy research : PTR
Phytotherapy research : PTR
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2024·1citation·S. Pace et al.·FASEB journal : official publication of the Federation of American Societies for Experimental Biology
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation
Elastic nano-liposomes (ENLs) with palmitoylethanolamide (PEA) show efficient transdermal delivery and enhanced skin retention, enhancing its anti-nociceptive and anti-inflammatory properties for topical application.
2024·1citation·Chuanpeng Ren et al.·Pharmaceutics
Pharmaceutics
Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders
Palmitoylethanolamide (PEA) shows potential in treating gastrointestinal disorders like irritable bowel syndrome and inflammatory bowel diseases due to its anti-inflammatory, antioxidant, and immunomodulatory properties.
2024·3citations·Marija Branković et al.·Antioxidants
Antioxidants
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain.
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Pharmacology & therapeutics