Pantoprazole

doi:10.2165/1153121-S0-000000000-00000

Paper

Pantoprazole

Published 2009 · Luis Moreira Dias

Clinical Drug Investigation

Q2 SJR score

28

Citations

1

Influential Citations

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Abstract

Pantoprazole is a proton pump inhibitor (PPI) that binds irreversibly and specifically to the proton pump, thereby reducing gastric acid secretion. Pantoprazole has a relatively long duration of action compared with other PPIs, and a lower propensity to become activated in slightly acidic body compartments. To date, no drug-drug interactions have been identified with pantoprazole in numerous interaction studies. Overall, in the short-term (8-10 weeks) initial treatment of gastro-oesophageal reflux disease (a condition that occurs when the reflux of gastric contents causes troublesome symptoms and/or complications) and long-term (6-24 months) maintenance therapy, oral pantoprazole 20 or 40 mg/day demonstrated similar efficacy to omeprazole, lansoprazole and esomeprazole and greater efficacy than histamine type 2 receptor antagonists. Pantoprazole is also effective in treating and preventing NSAID-related gastric and gastroduodenal injury. The optimal adult oral dose for gastric acid-related disorders is pantoprazole 40 mg once daily. Although data are limited, pantoprazole 20 or 40 mg/day was effective and well tolerated in the treatment of acid-related disorders in children and adolescents. Pantoprazole was also well tolerated in adults with acid-related disorders in short- and long-term studies. Thus, pantoprazole is a valuable agent for the management of acid-related disorders.

Rigorous Journal

Study Snapshot

Pantoprazole is an effective and well-tolerated proton pump inhibitor for treating acid-related disorders in adults and children.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Pantoprazole

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References

In reply to: Knowledge of developmental pharmacology and modeling approaches should be used to avoid useless trials in children

Off-label use of proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD) in children is appropriate based on consistent clinical evidence, avoiding unnecessary trial replication.

Management of NSAID-Induced Gastrointestinal Toxicity

Proton pump inhibitors (PPIs) are effective in treating NSAID-related dyspepsia and preventing upper gastrointestinal complications, but more controlled studies are needed to establish the best management strategy.

Single‐Dose Pharmacokinetics of Oral and Intravenous Pantoprazole in Children and Adolescents

Oral and intravenous pantoprazole have similar pharmacokinetic profiles in children aged 2-16 years, and both doses are safe and well-tolerated.

A clinical trial comparing pantoprazole and esomeprazole to explore the concept of achieving ‘complete remission’ in gastro‐oesophageal reflux disease

Pantoprazole and esomeprazole show potential in achieving complete remission in gastro-oesophageal reflux disease treatment, with esomeprazole showing better symptom relief.

Pantoprazole 40 mg Is as Effective as Esomeprazole 40 mg to Relieve Symptoms of Gastroesophageal Reflux Disease after 4 Weeks of Treatment and Superior regarding the Prevention of Symptomatic Relapse

Pantoprazole 40 mg is as effective as esomeprazole 40 mg for relieving GERD symptoms and has a significantly lower risk of relapse and fewer symptom episodes after treatment.

Citations

Design and synthesis of high quantum yield doped carbon nano probe derived from household sources for sensing of the anti-GERD drug pantoprazole.

The developed S,N-doped carbon nanomaterials (S,N-CNMs) are a green, cheap, and fast method for determining the anti-GERD drug pantoprazole in various matrices, with high selectivity and eco-friendliness.

The inadvertent consequences of drug recalls: A case study of a recall of pantoprazole generics from the markets

Recalls of pantoprazole-containing products led to a higher rate of potential drug-drug interactions, but the prevalence gradually decreased over time.

A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion

Celecoxib, naproxen, and diclofenac are effective in preventing heterotopic ossification after hip arthroplasty, but customized pharmacotherapy based on patients' comorbidities and medical history is needed.

An update on drug–drug interactions associated with proton pump inhibitors

Proton pump inhibitors (PPIs) have numerous drug-drug interactions, but their clinical relevance remains controversial.

Protective Effect of Pomegranate Peels Extracts Against Stomach Peptic-Ulcer Induced By Brexin In Albino Rats

Pomegranate peel extract (PPE) shows antiulcer activity and is recommended as a natural remedy against gastric mucosal injury induced by Brexin in albino rats.