A New Peptide Synthesis Using 2-Fluoro-1,3,5-trinitrobenzene. Syntheses of Thyrotropin Releasing Hormone and Leucine–Enkephalin

doi:10.1246/BCSJ.52.2619

Paper

A New Peptide Synthesis Using 2-Fluoro-1,3,5-trinitrobenzene. Syntheses of Thyrotropin Releasing Hormone and Leucine–Enkephalin

Published Sep 1, 1979 · H. Kinoshita, K. Inomata, O. Miyano

Bulletin of the Chemical Society of Japan

Q2 SJR score

14

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0

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Abstract

2-Fluoro-1,3,5-trinitrobenzene has been found to be a useful new condensing reagent for peptide synthesis. A variety of dipeptides have been prepared from the corresponding amino acids with the reagent. The Young test under certain conditions did not cause racemization during the procedures. Subsequent application of this reagent enabled the syntheses of thyrotropin releasing hormone and leucine-enkephalin in good yields.

Study Snapshot

2-Fluoro-1,3,5-trinitrobenzene is a useful new reagent for peptide synthesis, enabling the syntheses of thyrotropin releasing hormone and leucine-enkephalin in good yields.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A New Peptide Synthesis Using 2-Fluoro-1,3,5-trinitrobenzene. Syntheses of Thyrotropin Releasing Hormone and Leucine–Enkephalin

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References

Synthesis and optical studies of isoleucine oligopeptides in solution

This study successfully synthesized L-isoleucine oligopeptides using dicyclohexylcarbodiimide and acylazide coupling methods, with promising results for studying secondary structure in proteins and polypeptides.

Citations

4-Acetamidophenyl esters and 4-acetamidoanilides of L-arginine,p-guanidino-L-phenylalanine, L-lysine, N2-[D-fructos-3-O-yl and D-glucos-3-O-yl]acetyl-L-lysine as potential acrosin inhibitors

These compounds show potential as weak inhibitors of human acrosin and bovine trypsin, but require further evaluation for their full potential.

3,3′-(Phenylphosphinylidene)bis[2(3H)-benzoxazolone] and 3,3′-(Phenylphosphinylidene)bis[2(3H)-benzothiazolone]. New Activating Agents

New activating agents 4, 5 are useful for the preparation of amides, esters, and dipeptides under mild conditions, with potential applications in polyamide production.

A New and Effective Synthetic Method for the Preparation of the Esters, Peptides, and Lactones Using 3-(5-Nitro-2-oxo-1,2-dihydro-1-pyridyl)-1,2-benzisothiazole 1,1-Dioxide. Synthesis of (±)-(E)-8-Dodecen-11-olide, Recifeiolide

BID-NPy is a useful condensing reagent for preparing various esters, dipeptides, and lactones, and has been successfully employed in the synthesis of recifeiolide.

N,N′-Carbonyldi[1,2-benzisoxazol-3(2H)-one]: New, Reactive Condensing Agent

The new condensing agent N,N′-carbonyldi[1,2-benzisoxazol-3(2H)-one] (6) is useful for the preparation of amides, esters, and dipeptides under mild conditions, with potential for polyamide synthesis.

Studies on the β-Turn of Peptides. IV. Effect of the Chain Length on the CD Spectra of N-(2,4-Dinitrophenyl)-(Gly)n–D-Ala–L-Pro–(Gly)n p-Nitroanilides (n=1–3)

Chain length affects the conformation of N-(2,4-Dinitrophenyl)-(Gly)n-D-Ala-L-Pro-(Gly)n p-nitroanilides, with weaker Cotton effects and still some populations of folded conformers.

Studies of Unusual Amino Acids and Their Peptides. XIII. The Chemistry of N-(Carboxy methyl) amino Acids. II. The Synthesis of Peptides Containing N-(Carboxymethyl) amino Acids

N-(Carboxymethyl)amino acids can be synthesized into peptides using conventional methods, but diester-containing peptides require the acid chloride method.

A new peptide synthesis using 3-(succinimidoxy)-1,2-benzoisothiazole-1,1-dioxide. Application to synthesis of leucine-enkephalin.

This study demonstrates a new peptide synthesis method using 3-(succinimidoxy)-1,2-benzoisothiazole-1,1-dioxide for the synthesis of leucine-enkephalin in good yields.