The synthetic hepatic peptides pyroglutamylglutamylglycylserylasparagine and pyroglutamylglutamylglycylserylaspartic acid inhibit growth of MH1C1 rat hepatoma cells transplanted into Buffalo rats or athymic mice.

Paper

The synthetic hepatic peptides pyroglutamylglutamylglycylserylasparagine and pyroglutamylglutamylglycylserylaspartic acid inhibit growth of MH1C1 rat hepatoma cells transplanted into Buffalo rats or athymic mice.

Published Mar 1, 1992 · J. Paulsen, K. S. Hall, H. Rugstad

Cancer research

Q1 SJR score

9

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0

Influential Citations

Semantic Scholar

Abstract

Repeated i.p. injections of the synthetic peptides pyroglutamylglutamylglycylserylasparagine and pyroglutamylglutamylglycylserylaspartic acid inhibited the long-term growth of MH1C1 rat hepatoma cells by 50-70% in three in vivo models: metastatic colony growth in the lungs of young Buffalo rats; s.c. tumor growth in young Buffalo rats; and s.c. tumor growth in athymic mice. The amide free peptide pyroglutamylglutamylglycylserylaspartic acid which inhibited the tumor growth in all the models showed a curvilinear dose-response relationship with a maximal effect at 1000 pmol/animal in mice and at 100 pmol/animal in rats. The amidated peptide pyroglutamylglutamylglycylserylasparagine, which was only tested in the lung model, showed growth inhibition with 2, 20, or 200 pmol/animal, but 200 pmol/animal was most effective. We have recently reported that these peptides show cochromatography with hepatic growth inhibitory peptides, isolated from mouse liver.

Non-RCT

Animal Study

Study Snapshot

The synthetic peptides pyroglutamylglutamylglycylserylasparagine and pyroglutamylglycylserylaspartic acid effectively inhibit the growth of MH1C1 rat hepatoma cells by 50-7

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The synthetic hepatic peptides pyroglutamylglutamylglycylserylasparagine and pyroglutamylglutamylglycylserylaspartic acid inhibit growth of MH1C1 rat hepatoma cells transplanted into Buffalo rats or athymic mice.

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References

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The peptide pyroGlu-Gln-Gly-Ser-Asn, isolated from mouse liver, effectively inhibits rat hepatoma cell growth in vitro, potentially offering a potential treatment for hepatoma patients.

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Liver-derived growth inhibitor, transforming growth factor 1, and recombinant tumor necrosis factor all affect growth in different cell systems, with LDGI showing different growth regulatory effects than TGF-1 and rTNF- in some cell types.

An endogenous colon mitosis inhibitor reduces proliferation of colon carcinoma cells (HT 29) in serum-restricted medium

The endogenous colon mitosis inhibitor (pGlu-His-GlyOH) reduces colon carcinoma cell proliferation in serum-restricted medium, but its inhibitory effect is abolished by increasing serum content or adding insulin.

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Cell density reduces the binding of transforming growth factor beta, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor, with the effect differing from down regulation induced by specific growth factors and receptor transmodulation.

Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat.

TGF-beta 1 and TGF-beta 2 reversibly inhibit the liver's proliferative response to partial hepatectomy in rats, potentially impacting normal liver growth and repair.

Citations

Biochemical requirements of bioactive peptides for nutraceutical efficacy

Blocking N-terminal groups and C-terminal groups, as well as Ser/Thr/Tyr phosphorylation, can enhance the bioavailability of bioactive peptides for nutraceutical use by preventing digestion by digestive proteases.

Low MW Peptides and Carcinogenesis

Low MW peptides, which have growth inhibitory effects, are decreased in malignant cells compared to normal cells, suggesting they may play a role in carcinogenesis.

Chalones – From Aqueous Extracts To Oligopeptides

Chalones are tissue-specific growth inhibitors with a bell-shaped dose response pattern and optimal effect at very low concentrations, potentially altering growth- and differentiation-related gene expression.

Novel lymphocyte growth-inhibiting tripeptide: N-acetyl-glu-ser-GlyNH(2).

N-acetyl-Glu-Ser-GlyNH(2), a novel lymphocyte growth-inhibiting tripeptide, inhibits proliferation of T cell lymphoma cells but not normal human lymphocytes, suggesting its potential as a therapeutic agent for lymphoid malignancies.

Molecular Models of Acidic PePtides From Pea Bud Chromatin And Seminal Plasma. Divalent Cations-Mediated Interaction With Dna

Acidic peptides from pea bud chromatin and seminal plasma can bind to DNA and inhibit DNA transcription in the presence of divalent cations.