Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate.

doi:10.1016/S0278-6915(02)00323-X

Paper

Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate.

Published May 1, 2003 · Y. Ho, H. Ma, H-Y Chang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Chloral hydrate causes apoptosis in human lymphocytes, but not in Chang liver cells, and may signal caspase activation in lymphocytes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate.

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References

Mechanisms of caspase activation and inhibition during apoptosis.

Recent studies reveal a conserved mechanism of caspase activation and inhibition during apoptosis, improving our understanding of caspase regulation during apoptosis.

Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB.

The severe hepatic injury in CBDL rats is mediated by a vicious cycle involving overproduction of proinflammatory cytokines and activation of nuclear factor kappaB.

Cellular responses to tumor necrosis factor.

TNF-induced signaling pathways are common in various cell types, but their precise role in cell type specificity remains unclear.

Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2'-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene.

Biomarkers of apoptosis, such as release of cytochrome c and activation of caspase-3, can help predict apoptosis after exposure to environmental toxicants and help identify biological signs of increased risk for disease.

Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.

TCHQ, a major metabolite of PCP, causes more liver damage and oxidative stress in rats and human hepatoma cell lines than its parent compound, PCP.

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