R. B. Saraeva, I. Paskaleva, E. Doncheva
Dec 1, 2007
Citations
1
Influential Citations
43
Citations
Quality indicators
Journal
Journal of Clinical Pharmacy and Therapeutics
Abstract
Background and objective: Acenocoumarol (AC) is a coumarin derivative, vitamin K antagonist anticoagulant drug. It has a narrow therapeutic index and shows large pharmacokinetic and pharmacodynamic interindividual variability. Our objective was to investigate the association between AC dose requirements to achieve a target level of anticoagulation and genetic polymorphisms of genes possibly associated with its metabolism (CYP1A2, CYP2C9, CYP2C19, CYP3A4, CYP3A5) and transport (ABCB1).