Pharmacologic profile of amlodipine.

doi:10.1016/0002-9149(89)90956-9

Paper

DOI: 10.1016/0002-9149(89)90956-9

Pharmacologic profile of amlodipine.

Published Nov 7, 1989 · R. Burges, M. G. Dodd, Donald G. Gardiner

The American journal of cardiology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Amlodipine is a potent calcium antagonist and effective oral antihypertensive agent with natriuretic properties, making it a potential first-line treatment for hypertension.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1111/J.1749-6632.1988.TB33390.X

Amlodipine

Amlodipine effectively reduces blood pressure and has a sustained natriuretic effect in a long-term rat model of hypertension, offering potential for long-term treatment of hypertension.

1988·12citations·R. Burges et al.·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

DOI: 10.1016/s0022-3565(25)11016-1

Prolonged depolarization increases the pharmacological effect of dihydropyridines and their binding affinity for calcium channels of vascular smooth muscle.

Prolonged depolarization increases the pharmacological effect of dihydropyridines in vascular smooth muscle, suggesting that calcium channels in vascular smooth muscle are modulated by membrane potential similar to cardiac muscle.

1987·69citations·Nicole Morel et al.·The Journal of pharmacology and experimental therapeutics

The Journal of pharmacology and experimental therapeutics

DOI: 10.1097/00005344-198701000-00018

Calcium Channel Blocking Properties of Amlodipine in Vascular Smooth Muscle and Cardiac Muscle In Vitro: Evidence for Voltage Modulation of Vascular Dihydropyridine Receptors

Amlodipine is twice as potent as nifedipine in inhibiting calcium-induced contractions in vascular smooth muscle and cardiac muscle, with a very slow onset of action and voltage-dependent block of calcium channels.

1987·134citations·R. Burges et al.·Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

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Effects of Single and Repeated Doses of the Calcium Antagonist Felodipine on Blood Pressure, Renal Function, Electrolytes and Water Balance, and Renin‐Angiotensin-Aldosterone System in Hypertensive Patients

10 mg b.i.d. of felodipine effectively reduces blood pressure and has a definite natriuretic effect in hypertensive patients, with no significant antinatriuretic effect.

1986·43citations·G. Leonetti et al.·Journal of Cardiovascular Pharmacology

Journal of Cardiovascular Pharmacology

DOI:

Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.

The Ca2+ entry blocker receptor complex undergoes a temperature-dependent change, with all sites directly coupled at 37 degrees C, potentially impacting Ca2+ channel activity in vivo.

1986·78citations·M. L. Garcia et al.·The Journal of biological chemistry

The Journal of biological chemistry

Citations

DOI: 10.1016/j.sleep.2024.05.035

Effect of antihypertensive agents on sleep apnea and ambulatory blood pressure in patients with hypertension: A randomized controlled trial.

Chlorthalidone combined with amiloride and amlodipine are ineffective in decreasing sleep apnea episodes in patients with moderate sleep apnea and hypertension, but both treatments have comparable effects on lowering office and ambulatory blood pressure.

2024·0citations·F. T. Cichelero et al.·Sleep medicine

Sleep medicine

DOI: 10.1016/j.vascn.2024.107497

Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog.

Anesthetized dog models can effectively evaluate cardiovascular effects of drugs, with 10 out of 11 showing predicted changes based on their primary mechanisms of action and clinically reported effects.

2024·0citations·Olivera Antic et al.·Journal of pharmacological and toxicological methods

Journal of pharmacological and toxicological methods

DOI: 10.3390/molecules26102997

Direct Visualization of Amlodipine Intervention into Living Cells by Means of Fluorescence Microscopy

Direct visualization of amlodipine in living cells is possible due to enhanced emission in cellular environments, allowing for confocal time-lapse imaging and monitoring of drug uptake.

2021·6citations·C. Quentin et al.·Molecules

Molecules

DOI: 10.1016/j.lfs.2021.119043

Azelnidipine treatment reduces the expression of Cav1.2 protein.

Azelnidipine reduces the expression of Ca v 1.2 1c, which may partly explain its long-lasting hypotensive effect.

2021·2citations·Fumiaki Nasu et al.·Life sciences

Life sciences

DOI: 10.1002/bmc.5048

Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method; Application to a bioequivalence study.

The developed and validated LC-MS/MS method effectively determines amlodipine, indapamide, and perindopril in human plasma, making it suitable for clinical and pharmacokinetic investigations.

2020·16citations·M. Rezk et al.·Biomedical chromatography : BMC

Biomedical chromatography : BMC