Paper
Pharmacological review of isobavachalcone, a naturally occurring chalcone.
Published Feb 9, 2021 · Miao-miao Wang, Ligen Lin, Jin-jian Lu
Pharmacological research
Q1 SJR score
51
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Rigorous JournalStudy Snapshot
Isobavachalcone (IBC) shows potential as a promising lead compound for drug discovery due to its multiple pharmacological activities and potential targets, such as AKT and DHODH.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Simultaneous characterisation of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass Spectrometry for application in sex-related differences in pharmacokinetics.
The developed method accurately quantifies thirteen bioactive compounds in Psoraleae Fructus in rat plasma, revealing sex-related differences in pharmacokinetics.
2020·11citations·Zhi-xing Zhou et al.·Journal of separation science
Journal of separation science
Pancreatic lipase inhibitory constituents from Fructus Psoraleae.
Fructus Psoraleae contains bioactive compounds with lipid-lowering effects by targeting pancreatic lipase, suggesting potential for developing novel pancreatic lipase inhibitors.
2020·24citations·Xu-Dong Hou et al.·Chinese journal of natural medicines
Chinese journal of natural medicines
A novel target TAX1BP1 and P38/Nrf2 pathway independently involved in the anti-neuroinflammatory effect of isobavachalcone.
Isobavachalcone inhibits microglia activation through upregulation of TAX1BP1 and activation of P38/Nrf2 pathway, potentially aiding in preventing or treating neurodegenerative diseases.
2020·15citations·Zhipeng Li et al.·Free radical biology & medicine
Free radical biology & medicine
[Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP].
This study identified potential active ingredients in traditional Chinese medicine for COVID-19 prevention and treatment, with potential applications in cough, dyspnea, and fever treatments.
2020·29citations·Jing Ma et al.·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway
Psoralen, Isopsoralen, and Isobavachalcone from Psoralea corylifolia L. can improve hepatocyte damage and cholesterol accumulation in nonalcoholic fatty liver disease models by inhibiting the protein kinase C-/nicotinamide
2020·18citations·Li-Shan Zhou et al.·Frontiers in Pharmacology
Frontiers in Pharmacology
Citations
Mechanisms of Azole Potentiation: Insights from Drug Repurposing Approaches.
Drug repurposing strategies can advance antifungal therapy by enhancing azole potency through mechanisms such as inhibiting efflux pumps, intensifying ergosterol synthesis inhibition, and mitigating fungal cell resistance.
2025·0citations·Juan Xiong et al.·ACS infectious diseases
ACS infectious diseases
Natural sideromycins and siderophore-conjugated natural products as inspiration for novel antimicrobial agents.
Siderophore-antibiotic conjugates show promise as novel antimicrobial agents, enhancing uptake and efficacy against multidrug-resistant Gram-negative bacteria.
2025·0citations·Zhi-ying Miao et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
Natural products against tau hyperphosphorylation‐induced aggregates: Potential therapies for Alzheimer's disease
Natural products show potential in reducing tau hyperphosphorylation-induced aggregation, potentially offering a therapeutic alternative for Alzheimer's disease.
2025·0citations·Gustavo Basurto‐Islas et al.·Archiv Der Pharmazie
Archiv Der Pharmazie
Plant Volatile Methyl Salicylate Primes Wheat Defense Against the Grain Aphid by Altering the Synthesis of Defense Metabolites.
Methyl salicylate (MeSA) treatment in wheat increases its defense against grain aphids by altering the synthesis of defense metabolites, making it a potential phytoprotectant for crop protection and sustainable agriculture.
2024·0citations·Zhenxiang Li et al.·Plant, cell & environment
Plant, cell & environment
Synthesis and In-Vitro/Silico Evaluation of Fluorinated Chalcones
Fluorinated chalcones show promising antimicrobial and antifungal activity against Gram-positive and Gram-negative bacteria, with compound 1D showing the best binding affinity.
2024·0citations·Vilas Vane et al.·Oriental Journal Of Chemistry
Oriental Journal Of Chemistry
Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors.
Isobavachalcone shows significant antifungal activities against Candida albicans, inhibiting growth and virulence factors, with low cytotoxicity against mammalian cells, suggesting potential in developing antifungal therapies.
2024·2citations·Longfei Yang et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Synergy between isobavachalcone and doxorubicin suppressed the progression of anaplastic thyroid cancer through ferroptosis activation
The combination of isobavachalcone and doxorubicin effectively suppresses anaplastic thyroid cancer cell growth by activating ferroptosis, potentially offering a potent chemotherapy protocol for treating ATC.
2024·0citations·Shuai Lin et al.·Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research
Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism.
IBC and CA show potential as effective anti-JEV agents by targeting AMPK-associated signaling pathways, potentially offering broad-spectrum antiviral treatments for Flavivirus infections.
2024·2citations·Jiangxuan Zhou et al.·Journal of virology
Journal of virology