Pharmacologically active 4-oxo-4H-chromen-2-carboxylic acids. Part III. Mechanistic aspects of the decomposition of ethyl 6-azido-4-oxo-4H-chromen-2-carboxylate

doi:10.1039/J39710003079

Paper

Pharmacologically active 4-oxo-4H-chromen-2-carboxylic acids. Part III. Mechanistic aspects of the decomposition of ethyl 6-azido-4-oxo-4H-chromen-2-carboxylate

Published 1971 · M. I. Chohan, A. O. Fitton, B. Hatton

Journal of The Chemical Society C: Organic

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4

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Abstract

The mechanism of the decomposition of ethyl 6-azido-4-oxo-4H-chromen-2-carboxylate in the presence of polyphosphoric and acetic acids has been studied. The probable participation of ethyl 6-(N-acetoxyacetamido)-4-oxo-4H-chromen-2-carboxylate is discussed, and evidence is presented which indicates that this compound rearranges intermolecularly prior to oxazolochromone formation.

Study Snapshot

The decomposition of ethyl 6-azido-4-oxo-4H-chromen-2-carboxylate in the presence of polyphosphoric and acetic acids leads to the formation of oxazolochromone, a potent and selective pharmacological agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Pharmacologically active 4-oxo-4H-chromen-2-carboxylic acids. Part III. Mechanistic aspects of the decomposition of ethyl 6-azido-4-oxo-4H-chromen-2-carboxylate

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