Phenethyl Alcohol I. Effect on Macromolecular Synthesis of Escherichia coli

doi:10.1128/jb.89.5.1354-1369.1965

Paper

Phenethyl Alcohol I. Effect on Macromolecular Synthesis of Escherichia coli

Published May 1, 1965 · H. Rosenkranz, H. Carr, H. M. Rose

Journal of Bacteriology

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77

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0

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Abstract

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli. J. Bacteriol. 89:1354–1369. 1965.—An investigation of the mode of action of phenethyl alcohol produced the following results. Phenethyl alcohol had no effect on the physicochemical properties of isolated deoxyribonucleic acid (DNA). The DNA isolated from phenethyl alcohol-treated bacteria had physicochemical properties identical with those of DNA isolated from normal cells. The metabolic functions most sensitive to the inhibitory action of phenethyl alcohol appeared to be the process of enzyme induction and, possibly, the synthesis of messenger ribonucleic acid. Phenethyl alcohol did not affect the polyuridylic acid-mediated synthesis of polyphenylalanine in a cell-free amino acid-incorporating system.

In Vitro Study

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Study Snapshot

Phenethyl alcohol inhibits enzyme induction and messenger ribonucleic acid synthesis in Escherichia coli, but does not affect DNA physicochemical properties or polyuridylic acid-mediated polyphenylalanine synthesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Phenethyl Alcohol I. Effect on Macromolecular Synthesis of Escherichia coli

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References

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Citations

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Yeast volatile organic compounds significantly reduce the production of ochratoxin A in Aspergillus fungi, improving food safety and quality.

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Low levels of 2-phenylethanol stimulate Aspergillus flavus growth but decrease branched-chain amino acid degradation, suppressing aflatoxin biosynthesis and potentially affecting secondary metabolism.

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