Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations.

doi:10.1016/j.freeradbiomed.2014.06.008

Paper

DOI: 10.1016/j.freeradbiomed.2014.06.008

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations.

Published Sep 1, 2014 · Y. Yeh, Hua Yeh, Shu-hui Su

Free radical biology & medicine

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Abstract

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In Vitro Study

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Phenethyl isothiocyanate (PEITC) induces G2/M phase arrest and apoptosis in oral cancer cells through a GSH redox stress and oxidative DNA damage-induced ATM-Chk2-p53-related pathway.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1177/0960327113491508

Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways

PEITC induces apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species-mediated mitochondria-dependent pathways.

2014·35citations·S.-H. Huang et al.·Human & Experimental Toxicology

Human & Experimental Toxicology

DOI: 10.1016/j.abb.2014.01.022

Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G(1) arrest via the ATM/p53 pathway.

Non-thermal atmospheric pressure plasma (NTP) induces apoptosis in oral cavity squamous cell carcinoma through DNA damage and the ATM/p53 pathway, showing potential therapeutic potential for this cancer type.

2014·118citations·J. Chang et al.·Archives of biochemistry and biophysics

Archives of biochemistry and biophysics

DOI: 10.1186/1471-2407-13-571

Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells

Phenethyl isothiocyanate (PEITC) induces apoptosis in cholangiocarcinoma KKU-M214 cells and Chang cells through increased calcium mobilization and mitochondrial cell death pathway, with different effects in CCA and Chang cells.

2013·26citations·Ornanong Tusskorn et al.·BMC Cancer

BMC Cancer

DOI: 10.1016/j.freeradbiomed.2013.07.002

Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway.

Selenocystine enhances 5-fluorouracil-induced apoptosis in cancer cells by triggering DNA damage and inactivating the ERK pathway, suggesting potential anticancer synergism.

2013·101citations·Cundong Fan et al.·Free radical biology & medicine

Free radical biology & medicine

DOI: 10.1007/s00210-013-0906-8

Phenethyl isothiocyanate induces apoptosis of cholangiocarcinoma cells through interruption of glutathione and mitochondrial pathway

PEITC rapidly kills cholangiocarcinoma cells by disrupting glutathione redox and mitochondrial pathway, making it a promising chemopreventive agent for this aggressive cancer.

2013·27citations·Ornanong Tusskorn et al.·Naunyn-Schmiedeberg's Archives of Pharmacology

Naunyn-Schmiedeberg's Archives of Pharmacology

Citations

DOI: 10.3892/mmr.2024.13421

Epigenetic downregulation of the proapoptotic gene HOXA5 in oral squamous cell carcinoma

HOXA5 is an epigenetic downregulated proapoptotic gene in oral squamous cell carcinoma, potentially serving as a biomarker for detecting the disease and enhancing the therapeutic effect of cisplatin.

2024·0citations·Ying-Ju Chen et al.·Molecular Medicine Reports

Molecular Medicine Reports

DOI: 10.1002/mnfr.202400063

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights.

Phenethyl isothiocyanate (PEITC) shows potential as an anticancer agent, effectively targeting various cancer types and reducing metastasis through various mechanisms.

2024·0citations·Shahira M. Ezzat et al.·Molecular nutrition & food research

Molecular nutrition & food research

DOI: 10.1016/j.phrs.2024.107107

Isothiocyanates in Medicine: A Comprehensive Review on Phenylethyl-, Allyl-, and Benzyl-Isothiocyanates.

Phenylethyl isothiocyanate (PEITC), allyl isothiocyanate (AITC), and benzyl isothiocyanate (BITC) show potential as effective treatments for inflammatory diseases and infections, with potential anticancer properties.

2024·8citations·Cosima C. Hoch et al.·Pharmacological research

Pharmacological research

DOI: 10.1016/j.oraloncology.2023.106573

New insights into redox-related risk factors and therapeutic targets in oral squamous cell carcinoma.

Redox-related risk factors and therapeutic targets may offer potential additions to conventional treatment options for oral squamous cell carcinoma.

2023·5citations·Ina Dewenter et al.·Oral oncology

Oral oncology

DOI: 10.1002/med.21969

Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation

Phytochemicals show promising anticancer effects against oral cancer cells, but bioavailability concerns may limit their clinical application.

2023·11citations·J. T. Burcher et al.·Medicinal Research Reviews

Medicinal Research Reviews

DOI: 10.1016/j.bbadis.2023.166740

Phenethyl isothiocyanate induces oxidative cell death in osteosarcoma cells with regulation on mitochondrial network, function and metabolism.

PEITC induces oxidative cell death in osteosarcoma cells by regulating mitochondrial network, function, and metabolism, with mitochondria playing a significant role in deciding cell fate.

2023·5citations·Chen-xiao Zhen et al.·Biochimica et biophysica acta. Molecular basis of disease

Biochimica et biophysica acta. Molecular basis of disease

DOI: 10.3390/ijms24097824

Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial

Nutri-PEITC Jelly intake for 3 months is safe, stabilizes the disease, improves quality of life, and may re-activate p53 in advanced-stage oral and oropharyngeal cancer patients.

2023·2citations·A. Lam-ubol et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences

DOI: 10.4103/abr.abr_305_21

Effect of Nasturtium Extract on Oral Cancer

Nasturtium extract shows significant anticancer effects at concentrations above 1 mg/ml, suggesting it as a potential therapeutic agent for oral cancer.

2023·2citations·Amid B. Nilash et al.·Advanced Biomedical Research

Advanced Biomedical Research

DOI: 10.3390/ijms232113287

Gain of Function (GOF) Mutant p53 in Cancer—Current Therapeutic Approaches

Personalized treatments targeting mutant p53, such as APR-246, COTI-2, SAHA, and PEITC, show promise in improving cancer survival rates and comfort for oncogenic patients.

2022·23citations·Katarzyna A. Roszkowska et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences