Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.

doi:10.1016/j.bbrc.2011.04.115

Paper

Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.

Published Jun 3, 2011 · G. Lavoie, Y. St-Pierre

Biochemical and biophysical research communications

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Abstract

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In Vitro Study

Study Snapshot

Phosphorylation of DNMT1 at Ser154 by CDKs is important for its enzymatic activity and protein stability, potentially contributing to DNA hypermethylation in cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.

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References

Citations

The molecular basis of cell memory in mammals: The epigenetic cycle

Cell memory in mammals is supported by an epigenetic cycle, where reversible activities coordinated with cell cycle transitions create a multiphasic system for maintaining cell identity and differentiation in proliferating stem cell populations.

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Calcium signaling plays a crucial role in regulating epigenetic mechanisms, potentially leading to better therapeutic approaches for diseases like neurological disorders and cancer.

Comprehensive Analysis of DNA Methyltransferases Expression in Primary and Relapsed Ovarian Carcinoma

DNA methyltransferases (DNMTs) play a crucial role in ovarian cancer, contributing to carcinogenesis, recurrence, and chemotherapy resistance.

Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation

Cell geometry influences energy metabolism and cellular contractility in vascular smooth muscle cells, with square-shaped geometry impairing mitochondrial function and affecting vessel contractility.

Methylation alterations and advance of treatment in lymphoma.

Methylation alterations in lymphoma contribute to poor outcomes, and targeted therapies like azacitidine and decitabine can improve treatment efficacy and prognosis.

Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors

This review reveals complex regulation of DNA methyltransferase isoforms in breast tumor pathology, highlighting their importance in breast cancer development and progression.