W. Ahmad, M. Zaheer, Anamika Gupta
Sep 1, 2016
Citations
0
Influential Citations
8
Citations
Journal
Journal of Saudi Chemical Society
Abstract
Abstract The antihistaminic drug trimeprazine ( 1 , also known as alimemazine) is photolabile under UV-A light in aerobic conditions. Irradiation of a methanol solution of trimeprazine produces two photoproducts which were isolated as N,N2-trimethyl-3-(10 H -phenothiazin-10-yl sulfoxide) propan-1-amine ( 2 ) and N,2-dimethyl-3-(10 H -phenothiazin-10-yl) propan-1-amine ( 4 ). The formation of products was explained by the oxidative photodegradation of trimeprazine in an irreversible trapping of the self-photogenerated 1 O 2 by the type II photodynamic action of the drug. The generation of singlet oxygen during photolysis of trimeprazine was confirmed by singlet oxygen scavenger 2,5-dimethylfuran (2,5-DMF).