Yulei Xie, Shan Wang, Ju Yang
May 10, 2021
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Quality indicators
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Abstract
Background: Studies have shown that platelet-rich plasma (PRP) can enhance the effect of meniscus repair, but some studies have suggested different views on the role of PRP.Purpose: To determine whether PRP can enhance the effect of meniscus repair with respect to pain reduction and improved functionality and cure rate in patients with meniscus injury.Methods: By searching PubMed, EMBASE, Cochrane Library databases, clinicaltrials.gov, and the CNKI database from their inception till December 1, 2020, we performed a meta-analysis of RCTs reporting the results of the Pain Visual Analog Scale (VAS), Lysholm score, healing rate, and adverse events. The risk of bias is assessed using Cochrane’s collaborative tools. The summary results are expressed with effect size and 95% confidence interval, and sensitivity and subgroup analysis were performed.Results: The meta-analysis included eight RCTs and 431 patients. In general, compared with the control group, use of PRP during meniscus surgery significantly improved the VAS (SMD: -0.40, P=0.002, 95%CI: -0.66 to -0.15) and Lysholm score (MD: 4.86, P=0.0009, 95%CI: 1.98–7.75) of patients with meniscus injury, but the PRP enhancement technique showed no benefit in improving the cure rate of meniscus repair (risk ratio [RR]: 1.22, P=0.06, 95%CI: 0.99–1.51). No serious adverse events were reported in any study. Conclusion: PRP deserves further consideration as an enhancement program for meniscus repair. However, the evidence still needs to be interpreted carefully because of the quantity and quality of the included studies.