Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

doi:10.1021/JA00175A020

Paper

Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

Published Sep 1, 1990 · D. Bancroft, C. Lepre, S. Lippard

Journal of the American Chemical Society

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393

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1

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Abstract

The kinetics and mechanism of binding of the anticancer drug cis-diamminedichloroplatinum(II), or cis-DDP, and its inactive trans isomer to chicken erythrocyte DNA at 37 o C have been investigated by 195 Pt NMR spectroscopy. Both cis-and trans-DDP bind to DNA by two successive pseudo-first-order processes, forming monofunctional adducts ( 195 Pt NMR shifts near -2300 ppm) that subsequently close to bifunctional lesions (chemical shifts near -2450 ppm)

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Study Snapshot

Both cis- and trans-DDP bind to DNA through two pseudo-first-order processes, forming monofunctional adducts and bifunctional lesions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

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