The kinetics and mechanism of binding of the anticancer drug cis-diamminedichloroplatinum(II), or cis-DDP, and its inactive trans isomer to chicken erythrocyte DNA at 37 o C have been investigated by 195 Pt NMR spectroscopy. Both cis-and trans-DDP bind to DNA by two successive pseudo-first-order processes, forming monofunctional adducts ( 195 Pt NMR shifts near -2300 ppm) that subsequently close to bifunctional lesions (chemical shifts near -2450 ppm)

Both cis- and trans-DDP bind to DNA through two pseudo-first-order processes, forming monofunctional adducts and bifunctional lesions.

Paper

Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA

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