Potassium Phosphate as a Solid Base Catalyst for the Catalytic Transfer Hydrogenation of Aldehydes and Ketones

doi:10.1021/CS200299V

Paper

Potassium Phosphate as a Solid Base Catalyst for the Catalytic Transfer Hydrogenation of Aldehydes and Ketones

Published Oct 20, 2011 · R. Radhakrishan, D. Do, S. Jaenicke

ACS Catalysis

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73

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Abstract

Potassium triphosphate is a surprisingly active catalyst for the catalytic transfer hydrogenation of carbonyl compounds. A pretreatment at 600 °C is critical to obtain the active material. Temperature programmed desorption of CO2 indicates that sites of lower basicity were created after heat treatment for 5 h as compared to 1 h. With 2-propanol as hydride source, aromatic aldehydes were reduced to the corresponding alcohols with high rates. The presence of electron withdrawing chloro- and nitro-substituents at the benzene ring increases the rate of reaction compared with unsubstituted benzaldehyde, while electron donating methyl or 2-propyl groups has the opposite effect. Ketones were reduced with a lower rate of reaction than aldehydes. The role of K3PO4 as a heterogeneous catalyst is indicated by a complete lack of reaction in the absence of the solid base and by studies with competing substrates. The latter studies suggest that the catalytic transfer hydrogenation of benzaldehyde and chlorinated benzal...

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Potassium triphosphate (K3PO4) is a highly active catalyst for catalytic transfer hydrogenation of carbonyl compounds, reducing aromatic aldehydes and ketones to alcohols with high rates.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Potassium Phosphate as a Solid Base Catalyst for the Catalytic Transfer Hydrogenation of Aldehydes and Ketones

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References

Citations

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This study developed a regioselective method for synthesis of -halovinyl amides, which can serve as dual precursors for allyl halides and alkylidene carbenes, leading to functionalized indoles and pyrrolidones.

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DMSO-Assisted K3PO4-Catalyzed Cooperative Metal-Free, Base-Free Etherification of Chloroheteroarenes at Low Temperatures demonstrates good substrate scope under mild reaction conditions.

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