In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol.

doi:10.4049/jimmunol.153.4.1544

Paper

In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol.

Published Aug 15, 1994 · D. Padgett, R. Loria

Journal of immunology

Q1 SJR score

135

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1

Influential Citations

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Abstract

Dehydroepiandrosterone (5-androstene-3 beta-ol-17-one, DHEA) has been shown to protect mice from lethal viral and bacterial infections. However, recently, androstenediol (5-androstene-3 beta-17 beta-diol, AED) and androstenetriol (5-androstene-3 beta-7 beta-triol, AET), metabolites of DHEA, have each shown to be more potent endocrine regulators of the immune response. In contrast to glucocorticosteroids, in vivo, these steroid hormones up-regulated the cellular immune response of the host to limit virus-mediated pathology. These experiments first examined the in vitro influences of DHEA, and AED, or AET on mitogen-stimulated activation of murine lymphocytes. From physiologic to pharmacologic doses, DHEA suppressed proliferation of mixed splenocyte cultures activated with Con A or LPS by 20 to 70% whereas AED had little influence on the response. In sharp contrast, AET potentiated the response with both mitogens to 50 to 70% above control. Analogous to these observations was the regulation of IL-2 and IL-3 secretion from Con A-activated lymphocytes by each of these hormones which again was depressed analyzed. The suppressive effects of hydrocortisone on Con A-induced lymphocyte proliferation and cytokine production were strongly counteracted by coculture with AET. DHEA did not counteract hydrocortisone activity whereas AED showed moderate antiglucocorticoid function.

In Vitro Study

Highly Cited

Study Snapshot

Androstenetriol (AET) is a potent steroid hormone that enhances lymphocyte activation and protects against viral and bacterial infections, while DHEA suppresses lymphocyte proliferation and cytokine production.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

In vitro potentiation of lymphocyte activation by dehydroepiandrosterone, androstenediol, and androstenetriol.

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References

Citations

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Androstene hormones DHEA, 17-AED, 17-AED, and 17-AET are weak androgen and estrogen activators, with their biological effects varying depending on their interactions with these receptors.

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17-androstenediol treatment induces oncophagy in human tumor cells through either autophagy or apoptosis, with the tumor cell determining which pathway is utilized.