Pregabalin: From molecule to medicine

doi:10.1016/j.euroneuro.2006.04.005

Paper

Pregabalin: From molecule to medicine

Published Jul 1, 2006 · R. Kavoussi

European Neuropsychopharmacology

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149

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5

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

Pregabalin shows potential as an effective and well-tolerated treatment for generalized anxiety disorder, with a novel mechanism of action that modulates neurotransmitter release and reduces calcium influx at nerve terminals.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Pregabalin: From molecule to medicine

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References

Therapeutic options: Addressing the current dilemma

Newer treatments like SSRIs and SNRIs show promise for managing generalized anxiety disorder, but a more effective, faster-acting, safer, and better-tolerated drug is needed to eliminate symptoms and restore normal function.

The Biology and Pharmacology of Calcium Channel α2-δ Proteins Pfizer satellite symposium to the 2003 Society for Neuroscience Meeting Sheraton New Orleans Hotel New Orleans, LA November 10, 2003

Pregabalin and gabapentin, novel analgesic and anticonvulsant compounds, bind to calcium channel alpha2-delta proteins, offering potential benefits in pain and seizure management.

Efficacy of Pregabalin in the Treatment of Generalized Anxiety Disorder: Double-blind, Placebo-Controlled Comparison of BID versus TID Dosing

Pregabalin is an effective treatment for generalized anxiety disorder, with BID dosing showing similar efficacy and comparable tolerability to TID dosing.

Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

Gabapentin and pregabalin reduce the release of sensory neuropeptides in the spinal cord only after significant inflammation or protein kinase C activation.

The neurobiology and control of anxious states

This paper explores the complex neurobiology of anxiety disorders, highlighting the roles of various modulators and potential new targets for treatment, while emphasizing the importance of behavioral models in understanding and managing anxious states.

A Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Multicenter Study of Pregabalin in Patients With Generalized Anxiety Disorder

Pregabalin is effective and well-tolerated in short-term therapy for generalized anxiety disorder.

Pregabalin in generalized anxiety disorder: a placebo-controlled trial.

Pregabalin is an effective, rapidly acting, and safe treatment for generalized anxiety disorder, with no withdrawal symptoms associated with short-term use.

Citations