Li‐Hui Lu, Jia‐Hao Wu, Chia‐Hsi Yang
Apr 1, 2008
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0
Influential Citations
24
Citations
Journal
Journal of The Chinese Chemical Society
Abstract
1H-1,2,3-triazoles can be prepared in good yield by the reaction of terminal alkyne and sodium azide in the presence of cuprous chloride at a temperature higher than 70 °C. The alkyne is unactivated and the reaction has to be carried out under inert gas. At room temperature, the reaction first gives a Cu(I)-azide complex which is converted to a Cu-alkyne complex when the temperature is raised to higher than 70 °C. The reaction of Cu(I)-alkyne complex and azide ion dissociated from or coordinated to Cu(I) then gives 1H-1,2,3-triazoles.