Hua Zhang, Peng Yan, Guo-lin Zhang
Jun 1, 2006
Citations
0
Influential Citations
5
Citations
Journal
Synthesis
Abstract
2-(1-Chloroalkyl)-4,5-dimethyloxazoles were prepared in 84-91% yields by simultaneous reduction and regioselective chlorination of the corresponding unstable N-oxides with POCl3 or SOCl2. Dehydrochlorination of 2-(1-chloroalkyl)-4,5-dimethyloxazoles with potassium hydroxide afforded (E)-2-alkenyl-4,5-dimethyloxazoles in 71-90% yields.