Zhong-Qian Wu
2011
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Journal
Chemical Reagents
Abstract
Firstly,2-(2-aminoethoxy)ethanol reacted with di-tert-butyl dicarbonate(Boc2O) in ethanol solution for protecting the amino group.Then the condensation of the thereby obtained tert-butyl-(2-(2-hydroxy) ethyl) carbamate with 1-bromo-6-chlorohexane was carried out in the presence of NaOH(50%) and tetrabutylammonium bromide to form tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate.Finally,tert-butyl(2-(2-(6-chlorohexy)oxy)ethyl)carbamate was subjected to de-protection in a mixture of dichloromethane and trifluoroacetic acid to yield(2-(2-(6-chlorohexy)oxy)ethyl)carbamate,with an overall yield reaching 11.4%.