Z. Demko, K. Sharpless
Nov 3, 2001
Citations
2
Influential Citations
794
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Journal
The Journal of organic chemistry
Abstract
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.