Taotao Dai, Le Tat Thanh, P. Long
Dec 23, 2015
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Abstract
Erlotinib hydrochloride (Tarceva) is a targeted cancer therapy drug approved for treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. An efficient and economical synthetic method of title compound from ethyl 3,4-dihydroxybenzoate is described in 6 steps with overall yield of 51 %.