Chen Huan-you
2012
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Journal
Modern Agrochemicals
Abstract
4-Fluoro-3-trifluoromethylnitrobenzene was synthesized by nitrification reaction of 2-fluorobenzotrifluoride using sulfuric acid and nitric acid,then it was reduced by hydrazine hydrate to give 4-fluoro-3-trifluoromethylaniline.In the solution of concentrated H2SO4,4-fluoro-3-trifluoromethylaniline was diazotized and hydrolyzed to give 4-fluoro-3-trifluoromethylphenol.Ethyl 2-bromobutyrate reacted with 4-fluoro-3-trifluoromethylphenol to give ethyl 2-(4-fluoro-3-trifluoromethylphenoxy) butyrate,then it reacted with benzylamine to give the target compound beflubutamid.The total yield is 52.3%.