Prochlorperazine induces central antinociception mediated by the muscarinic system.

doi:10.1016/J.PHRS.2004.02.005

Paper

DOI: 10.1016/J.PHRS.2004.02.005

Prochlorperazine induces central antinociception mediated by the muscarinic system.

Published Sep 1, 2004 · C. Ghelardini, N. Galeotti, C. Uslenghi

Pharmacological research

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Prochlorperazine increases pain threshold through a central cholinergic mechanism, preventing pain induced by muscarinic receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1038/sj.bjp.0703268

Loss of muscarinic antinociception by antisense inhibition of M1 receptors

Antisense inhibition of M1 muscarinic receptors in mice effectively inhibits central cholinergic analgesia, indicating its fundamental role in central pain perception.

2000·58citations·C. Ghelardini et al.·British Journal of Pharmacology

British Journal of Pharmacology

DOI: 10.1046/J.1365-2346.1999.00561.X

An assessment of prochlorperazine buccal for the prevention of nausea and vomiting during intravenous patient-controlled analgesia with morphine following abdominal hysterectomy.

Prochlorperazine buccal is an effective, inexpensive option for preventing post-operative nausea and vomiting in patients using intravenous patient-controlled analgesia with morphine after abdominal hysterectomy.

1999·28citations·P. I. Williams et al.·European journal of anaesthesiology

European journal of anaesthesiology

DOI: 10.1016/S0959-8049(98)00161-0

Efficacy of 5-HT3 receptor antagonists in radiotherapy-induced nausea and vomiting: a quantitative systematic review.

5-HT3 receptor antagonists may help prevent acute vomiting in radiotherapy patients, but their long-term effectiveness and potential harms remain unclear.

1998·50citations·M. Tramèr et al.·European journal of cancer

European journal of cancer

DOI: 10.1038/sj.bjp.0701327

D2 dopamine receptors and modulation of spontaneous acetylcholine (ACh) release from rat striatal synaptosomes

Quinpirole and 7-OH-DPAT inhibit spontaneous acetylcholine release from rat striatal synaptosomes, with this effect being competitively antagonized by haloperidol and likely mediated through dopamine D2 receptors.

1997·18citations·M. Clos et al.·British Journal of Pharmacology

British Journal of Pharmacology

DOI: 10.1016/S0304-3940(97)00345-5

Augmentation of opioid induced antinociception by the atypical antipsychotic drug risperidone in mice

Risperidone has a potent antinociceptive effect in mice, suggesting a potential role for it in pain management and opiate withdrawal management.

1997·37citations·S. Schreiber et al.·Neuroscience Letters

Neuroscience Letters

Citations

DOI: 10.1101/2023.09.16.557753

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy

Enhancing KCC2 function in neurons reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy.

2023·1citation·Florian Donneger et al.·bioRxiv

bioRxiv

DOI: 10.1208/s12249-022-02307-8

Development of Optimized Sumatriptan–Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization

Optimized sumatriptan-prochlorperazine orodispersible films with no disintegrant can effectively release drugs for migraine relief, providing rapid drug release and palatable disintegration.

2022·4citations·Sana Javed et al.·AAPS PharmSciTech

AAPS PharmSciTech

DOI:

Simultaneous quantification of sumatriptan succinate and prochlorperazine maleate in orodispersible films using two validated UV-spectroscopic methods.

Both methods are simple, reliable, and robust for simultaneous quantification of sumatriptan succinate and prochlorperazine maleate in orodispersible films.

2022·3citations·Sana Javed et al.·Pakistan journal of pharmaceutical sciences

Pakistan journal of pharmaceutical sciences

DOI: 10.1371/journal.pone.0164998

Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant

Choisya 'Aztec-Pearl' leaves exhibit high antinociceptive activity, with anhydroevoxine and choisyine contributing to this effect, and no significant toxic effects were observed.

2016·8citations·Patricia Ribeiro de Carvalho et al.·PLoS ONE

PLoS ONE

DOI: 10.1016/j.ejphar.2015.07.039

Induction and antagonism of pica induced by teriparatide in rats.

Teriparatide-induced pica in ovariectomized rats can be inhibited by antagonists of serotonin 5-HT3, dopamine D2, neurokinin NK 1, and histamine H 1, potentially serving as treatments for teriparatide-induced nausea in human patients.

2015·5citations·Kouichi Yamamoto et al.·European journal of pharmacology

European journal of pharmacology