Donna D. Yu, B. M. Forman
Oct 30, 2003
Citations
2
Influential Citations
40
Citations
Journal
The Journal of organic chemistry
Abstract
A McMurry coupling reaction and selective crystallization were used to develop a simple and efficient two-step synthesis of (Z)-4-hydroxytamoxifen (2a). This compound is an active metabolite of tamoxifen, a selective estrogen receptor (ER) modulator widely used to treat breast cancer. The synthesis employed 1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene (1) as a useful building block.