Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action.

doi:10.1016/J.EJPHAR.2006.10.003

Paper

DOI: 10.1016/J.EJPHAR.2006.10.003

Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action.

Published Jan 26, 2007 · L. Savegnago, Larissa G. Pinto, C. Jessé

European journal of pharmacology

Q1 SJR score

123

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Diphenyl diselenide effectively reduces pain and paw oedema in mice, interacting with both the nitrergic system and glutamate receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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(-)-Linalool inhibits in vitro NO formation: Probable involvement in the antinociceptive activity of this monoterpene compound.

(-)-linalool's antinociceptive effect is partially due to its ability to reduce nitric oxide production/release, likely through cholinergic and glutamatergic systems.

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Diphenyl diselenide's antinociceptive effect is mediated through serotonergic pathways, unlike opioid, dopaminergic, and muscarinic cholinergic receptors.

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A tachykinin NK1 receptor antagonist attenuates the 4 beta-phorbol-12-myristate-13-acetate-induced nociceptive behaviour in the rat.

Ezlopitant, a tachykinin NK1 receptor antagonist, effectively reduces pain associated with peripheral inflammation in rats.

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Evidence for the involvement of metabotropic glutamatergic, neurokinin 1 receptor pathways and protein kinase C in the antinociceptive effect of dipyrone in mice

Dipyrone reduces pain in mice by inhibiting metabotropic glutamatergic and neurokinin NK1 receptor responses, and activating protein kinase C-dependent pathways.

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Citations

DOI: 10.1016/j.arres.2023.100092

EFFECT OF m-TRIFLUOROMETHYL- ATTACHMENT ON THE GLUTATHIONE PEROXIDASE MIMICRY AND ANTIOXIDANT ACTIONS OF DIPHENYL DISELENIDE: ESSENTIAL THIOLS OF ELECTROGENIC SODIUM PUMP AS A MECHANISTIC COMPONENT

The introduction of a -CF3 group to DFDD's aromatic rings does not abolish its GPx mimetic and antioxidant properties, which still rely on cerebral electrogenic sodium pump thiols.

2023·0citations·E. M. Ale et al.·Advances in Redox Research

Advances in Redox Research

DOI: 10.1021/acs.joc.2c03102

Copper-Catalyzed Cascade Multicomponent Reaction of Azides, Alkynes, and Selenium: Synthesis of Ditriazolyl Diselenides.

Copper-catalyzed cascade multicomponent reaction effectively synthesizes ditriazolyl diselenides from azides, terminal alkynes, and selenium under mild conditions.

2023·3citations·Bo Sun et al.·The Journal of organic chemistry

The Journal of organic chemistry

DOI: 10.1016/j.tetlet.2022.154255

Metal-Free Synthesis of Diselenides and Ditellurides by using TMSCN

TMSCN can effectively synthesize metal-free diselenides and ditellurides from boronic acids and elemental selenium, with a radical-mediated reaction mechanism.

2022·1citation·Chuan-Li Chen et al.·Tetrahedron Letters

Tetrahedron Letters

DOI: 10.1021/acschemneuro.2c00129

Antidepressant-Like Effect of a Selenoindolizine in Mice: In Vivo and In Silico Evidence for the Involvement of the Serotonergic 5-HT2A/C Receptors.

The selenium compound SeI shows antidepressant-like effects in mice, involving the serotonergic system and showing low potential for adverse effects.

2022·10citations·C. S. Garcia et al.·ACS chemical neuroscience

ACS chemical neuroscience

DOI: 10.1016/j.cbi.2022.109918

Antinociceptive effect of N-(3-(phenylselanyl)prop-2-yn-1-yl)benzamide in mice: Involvement of 5-HT1A and 5-HT2A/2C receptors.

SePB, an organoselenium compound, shows antinociceptive effects in mice models, with 5-HT1A and 5-HT2A/2C receptors involved in this effect.

2022·4citations·Kauane Nayara Bahr Ledebuhr et al.·Chemico-biological interactions

Chemico-biological interactions