Guanglin Luo, Ling Chen, G. Dubowchik
Jun 3, 2006
Citations
1
Influential Citations
49
Citations
Journal
The Journal of organic chemistry
Abstract
Indazoles are regioselectively protected at N-2 by a 2-(trimethylsilyl)ethoxymethyl (SEM) group using novel conditions. The SEM group can efficiently direct regioselective C-3 lithiation, and the resulting nucleophile can react with a wide range of electrophiles to generate novel indazole derivatives. The SEM group can be removed by treatment with TBAF in THF or aqueous HCl in EtOH.