M. Elliott, N. F. Janes, B. C. Pearson
1971
Citations
0
Influential Citations
20
Citations
Journal
Journal of the Chemical Society. Perkin transactions 1
Abstract
Chloromethylation of 3-furoates, followed by a Friedel–Crafts reaction, gives 5-aralkyl-3-furoates. Such compounds and the corresponding 3-thenoates are more conveniently synthesised by condensing the ethylene acetals of 5-substituted levulinic esters with ethyl formate. The resulting 2-formyl-4-oxo-ester derivatives are cyclised directly by aqueous acids to give furans, and by phosphorus pentasulphide to give the corresponding thiophens.