J. Pesti, G. Huhn, J. Yin
Oct 21, 2000
Citations
0
Influential Citations
10
Citations
Journal
The Journal of organic chemistry
Abstract
2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the cognition enhancer drug candidate 1. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis.