B. Wolfson, J. Tuazon, E. Siker
Nov 1, 1969
Citations
0
Influential Citations
8
Citations
Journal
Anesthesia & Analgesia
Abstract
VER two decades ago, Adamsl suggested 0 that an antidote such as physostigmine or neostigmine should be available whenever curare was used as a muscle relaxant during anesthesia. Neostigmine has been used for this purpose for many years by most anesthesiologists, since it is the only commercially available anticholinesterase in parenteral form. In the treatment of myasthenia gravis, oral neostigmine bromide has in large measure been replaced by pyridostigmine bromide, which produces fewer gastrointestinal side effects, has a longer duration of action, and gives a more even level of sustained muscle strength.2