Paper
Quetiapine improves response inhibition in alcohol dependent patients: A placebo-controlled pilot study
Published Jan 31, 2012 · Nathasha R. Moallem, L. Ray
Pharmacology Biochemistry and Behavior
Q1 SJR score
22
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
RCTStudy Snapshot
Quetiapine improves response inhibition in alcohol dependent patients, suggesting a potential mechanism of action for its treatment in alcohol use disorders.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving
Quetiapine effectively reduces alcohol cravings and subjective intoxication in alcohol-dependent individuals, improving their biobehavioral response to alcohol.
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A double-blind, placebo-controlled, randomized pilot study comparing quetiapine with placebo, associated to naltrexone, in the treatment of alcohol-dependent patients.
Quetiapine and naltrexone combined showed no additional benefit compared to naltrexone alone for alcohol-dependent patients.
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Citations
The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature.
Non-psychedelic 5-HT2A agents show mixed results in treating substance use disorders, but 5-HT2A receptor agonists show more promising results.
2024·0citations·Alejandra Pulido-Saavedra et al.·Expert opinion on pharmacotherapy
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Acute alcohol intoxication impairs response inhibition, with larger effects at higher alcohol concentrations and under prepotent response sets.
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Neurobiological mechanisms of control in alcohol use disorder – Moving towards mechanism-based non-invasive brain stimulation treatments
Non-invasive brain stimulation treatments like TMS and tDCS may help re-establish the functional balance between controlled and automatic behavior in alcohol use disorder patients.
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The Association Between Impulsivity and Relapse in Patients With Alcohol Use Disorder: A Literature Review.
All three facets of impulsivity (trait, motor, and impulsive choice) are associated with alcohol use disorder relapse, but no one factor is superior to another.
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Do alcohol-dependent patients show different neural activation during response inhibition than healthy controls in an alcohol-related fMRI go/no-go-task?
Alcohol-dependent patients show enhanced neural activity during response inhibition, potentially compensating for impaired cognitive processing, compared to healthy controls.
2017·47citations·Marta Czapla et al.·Psychopharmacology
Psychopharmacology
Potential Medications for the Treatment of Alcohol Use Disorder: An Evaluation of Clinical Efficacy and Safety
Alternative medications for alcohol use disorder show mixed effectiveness and safety, with some showing good results with mild side effects, while others show poor results.
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Substance Abuse
A DOUBLE - BLIND, PLACEBO - CONTROLLED, RANDOMIZED STUDY COMPARING QUETIAPINE WITH PLACEBO, ALONG WITH ORAL NALTREXONE, IN THE TREATMENT OF OPIOID DEPENDENT PATIENTS
Using Quetiapine along with Naltrexone significantly decreases relapse rate and increases days of abstinence in opioid dependent patients after inpatient detoxification.
2015·8citations·Harsh Chalana et al.·Journal of Evolution of medical and Dental Sciences
Journal of Evolution of medical and Dental Sciences