N. White, S. Looareesuwan, D. Warrell
1983
Citations
7
Influential Citations
150
Citations
Quality indicators
Journal
The American journal of tropical medicine and hygiene
Abstract
In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.