Quinolones Substituted by Different Moieties. Part 3. Reactions of 1,2- Dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carbaldehyde with Some Cyclic Active Methylene Compounds.

doi:10.1002/CHIN.199739170

Paper

Quinolones Substituted by Different Moieties. Part 3. Reactions of 1,2- Dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carbaldehyde with Some Cyclic Active Methylene Compounds.

Published Sep 23, 1997 · M. M. Ismail, E. A. Mohamed, M. Abass

ChemInform

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Abstract

l,2-Dihydro-4-hydroxy-l-methyl-2-oxoquinoline-3-carbaldehyde has been reacted with some cyclic active methylene compounds, viz. l,2-dihydro-4-hydroxy-l-methyl-2-oxoquinoline, 1-substituted 2thiobarbituric acids, and 2-phenylimino-3-oxothiazolidine. The obtained exocyclic enone systems were reacted with hydrazine hydrate giving rise to the 3-pyrazolinylquinoline derivatives. All the given structures were verified by elemental analyses and spectral data.

Study Snapshot

This study demonstrates the successful synthesis of 3-pyrazolinylquinoline derivatives by reacting 1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carbaldehyde with various cyclic active methylene compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Quinolones Substituted by Different Moieties. Part 3. Reactions of 1,2- Dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carbaldehyde with Some Cyclic Active Methylene Compounds.

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References

Citations

Synthesis, antibacterial activity and docking studies of substituted quinolone thiosemicarbazones

Substituted quinolone thiosemicarbazones show promising antibacterial activity against various bacteria, with the best activity seen when larger halogens and phenyl groups are present.

Substituted pyridopyrimidinones. Part 5. Behavior of 2-hydroxy-4-oxo-4H-pyrido[1,2-α]pyrimidine-3-carbaldehyde in nucleophilic condensation reactions

This study demonstrates the reactivity of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde towards N- and C-nucleophiles, leading to the synthesis of new enaminones, Schiff's bases