N. Robertson, Lu Jiang, R. Ramage
Feb 26, 1999
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron
Abstract
Abstract A novel coupling reagent ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate has been developed for use in conjunction with diisopropylcarbodiimide for solid phase peptide synthesis. The synthesis and application of this reagent in solid phase peptide synthesis has been reported. Here we report a systematic study into racemisation upon activation and coupling of single amino acids and dipeptides with this reagent. A novel coupling reagent ethyl 1-hydroxy-1H-1,2,3-triazole-4-carboxylate has been developed for use in conjunction with diisopropylcarbodiimide for solid phase peptide synthesis. The synthesis and application of this reagent in solid phase peptide synthesis has been reported. Here we report a systematic study into racemisation upon activation and coupling of single amino acids and dipeptides with this reagent.