T. Kaiser, G. Nicholson, H. Kohlbau
Feb 19, 1996
Citations
0
Influential Citations
44
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In conventional stepwise Fmoc solid phase peptide synthesis, diisopropylethylamine (DIEA) base-catalyzed acylation methods lead to considerable amounts of racemization of Fmoc-Cys(Trt) residues during the activation/coupling process. The epimerization can be reduced to a negligible degree, via a base-free activation step.