Tobias Gabriel, L. Wessjohann
Feb 24, 1997
Citations
0
Influential Citations
43
Citations
Journal
Tetrahedron Letters
Abstract
Abstract In a two step, one pot reaction of 4-benzyl oxazolidinone, 2-bromoacetyl halide, chromium dichloride and a suitable 3-oxo-aldehyde derivative the C1C6Me - fragment of epothilons is available in its correct oxidation state and enantiomeric form. Compared to common methods, the chromium-Reformatsky variation preferentially yields the opposite diastereomers and gives improved chemo- and diastereoselection.