Reaction of Methyl 2-Bensoylamino-3-dimethylaminopropenoate with Heterocycilc Hydroxy Compounds. The Synthesis of Fused Pyranoazines

doi:10.3987/COM-93-S(T)135

Paper

Reaction of Methyl 2-Bensoylamino-3-dimethylaminopropenoate with Heterocycilc Hydroxy Compounds. The Synthesis of Fused Pyranoazines

Published 1993 · B. Stanovnik, M. Kmetič, Branko Stanovnic

Heterocycles

Q4 SJR score

11

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0

Influential Citations

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Abstract

Methyl 2-benzoylamino-3-dimethylaminopropenoate (1) reacts in acetic acid with monocyclic or bicyclic heterocyclic compounds with two hydroxy or potential hydroxy groups in 1,3-position to give fused pyranones. Accordingly, derivatives of 2H-pyrano[3,2-c]pyridine (3), 2H-pyrano[3,2-c]quinoline (9, 10,and 11), 2H-pyrano[2,3-d]pyridazine (13), 8H-pyrano[3,2-d]tetrazolo[1,5-b]pyridazine (16), pyrano[4,3-b]pyran (18), and 2H-pyrano[2,3-c]-pyridine (22) were obtained

Study Snapshot

Methyl 2-benzoylamino-3-dimethylaminopropenoate reacts with heterocyclic compounds with two hydroxy groups in 1,3-position to produce fused pyranones.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Reaction of Methyl 2-Bensoylamino-3-dimethylaminopropenoate with Heterocycilc Hydroxy Compounds. The Synthesis of Fused Pyranoazines

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References

Citations

Enaminone, Enaminoesters, and Related Compounds in the Metal-Free Synthesis of Pyridines and Fused Pyridines

Enaminones, enaminoesters, and related compounds enable metal-free synthesis of pyridines and fused pyridines, pyridyl-substituted amino acids, hydroxy acids, and polyols.

Chemistry of 4-hydroxy-2(1H)-quinolone. Part 2. As synthons in heterocyclic synthesis

4-hydroxy-2(1H)-quinolone is a useful building block for heterocyclic compounds, with potential applications in various fields.

Single-step synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines

This method allows for the synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines in a single-step process, with potential applications in pharmaceuticals and nutraceuticals.

Synthesis of 4-aryl-5-hydroxy- and 5-aryl-4-hydroxypyridazin-3(2H)-ones and their use in the preparation of 4,5-diarylpyridazin-3(2H)-ones and hitherto unknown isochromeno[3,4-d]pyridazinediones

This study demonstrates the synthesis of 4-aryl-5-hydroxy- and 5-aryl-4-hydroxypyridazin-3(2H)-ones, which can be used to synthesize 4,5-diarylpyridazin-3(2H)-ones and unknown isochromen

Diethyl N,N‐dimethylaminomethylenemalonate in the synthesis of fused heterocyclic systems

Diethyl N,N-dimethylaminomethylenemalonate can be used to synthesize fused heterocyclic systems with various methylene groups, such as pyrazole, pyrimidine, and pyridine derivatives.

Rearrangements of 5-acetyl-3-benzoylamino-6-(2-dimethylamino-1-ethenyl)-2H-pyran-2-one and 3-benzoylamino-6-(2-dimethylamino-1-ethenyl)-5-ethoxycarbonyl-2H-pyran-2-one into 1-aminopyridine, pyrano[2,3-b]pyridine and isoxazole derivatives

This study demonstrates that 5-acetyl-3-benzoylamino-6-(2-dimethylamino-1-ethenyl)-2H-pyran-2-one and 3-benzoylamino-6-(2-dimethylamino-1-ethenyl)

The synthesis of 5-substituted 3-benzoylamino-6-(2-substituted amino-1-ethenyl)-2H-pyran-2-ones and their transformations into 2H-pyrano[3,2-c]pyridine derivatives†

This new approach allows for the synthesis of 2H-pyrano[3,2-c]pyridine derivatives with various functional groups, such as -amino acid, -amino acid, and -amino acid.