A. A. Sabitov, M. Dmitriev, A. I. Belozerova
Jul 1, 2020
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Journal
Russian Journal of Organic Chemistry
Abstract
Three-component condensation of ethyl 1-R-2-phenyl-4,5-dihydro-4,5-dioxo-1H-pyrrole-3-carboxylates, malononitrile, and acyclic enols (acetylacetone, alkyl acetoacetates, and ethyl benzoylacetate) afforded substituted ethyl 9-amino-10-cyano-1-oxo-3-phenyl-8-oxa-2-azaspiro[4.5]deca-3,6,9-triene-4-carboxylates. The products are interesting from the viewpoint of medicinal chemistry.