Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives

doi:10.1071/C97034

Paper

Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives

Published 1997 · C. Easton, S. Lincoln, B. May

Australian Journal of Chemistry

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Abstract

Reactions of 6A-amino-6A-deoxy-β-cyclodextrin and 3A-amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin with the 3-nitrophenyl esters of 2-phenylpropanoic acid and Ibuprofen occur with only low diastereoselectivity, to afford the corresponding arylpropanamido-substituted cyclodextrins. These amides are also formed by decarboxylation of corresponding malonates, again with only low diastereoselectivity. The n.m.r. spectra of the amido-substituted cyclodextrins indicate that the aryl substituent is included within the cyclodextrin annulus at low temperature, but becomes dissociated from the cavity as the temperature is increased.

Study Snapshot

Amino-substituted cyclodextrins can form arylpropanamido-substituted cyclodextrins with low diastereoselectivity, forming amides with low diastereoselectivity and low di

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Reactions of Amino-Substituted Cyclodextrins with 2-Arylpropanoic Acid Derivatives

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