Reactivity of 5-nitro-2-furaldehyde in alkaline and acidic solutions.

Paper

Reactivity of 5-nitro-2-furaldehyde in alkaline and acidic solutions.

Published Nov 1, 2001 · A. Cisak, K. Rzeszowska-Modzelewska, E. Brzezińska

Acta poloniae pharmaceutica

Q3 SJR score

3

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0

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Abstract

5-Nitro-2-furaldehyde (NFA) forms in alkaline solutions an anion of nitronic acid of (5-nitro-furan-2-yl)-methanediol. Upon acidification (5-nitro-furan-2-yl)-methanediol (HNFA) appears with pKa=4.6. Then, in a novel irreversible redox ring-opening reaction, nitrile oxide of alpha-ketoglutaconic acid is formed which hydrolyses in acidic solutions. With increasing pH it dimerizes to furoxane or polymerizes to hydraxamates. Some of the products were separated and identified by IR and NMR spectroscopy, confirmed by elemental analysis.

Study Snapshot

5-Nitro-2-furaldehyde reacts in alkaline and acidic solutions to form anion, nitronic acid, and nitrile oxide, which hydrolyzes in acidic solutions and forms various products.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Reactivity of 5-nitro-2-furaldehyde in alkaline and acidic solutions.

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References

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