EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival

doi:10.1038/sj.onc.1209694

Paper

EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival

Published Nov 9, 2006 · M. Kamiyama, A. Pozzi, Li Yang

Oncogene

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127

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

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EP2, a receptor for PGE2, directly regulates tumor angiogenesis by contributing to cell survival and endothelial cell motility in endothelium.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival

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References

Citations

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Solid lipid nanoparticles encapsulating a benzoxanthene derivative show potential in modulating VEGF effects and reducing angiogenesis and inflammation in VEGF-induced angiogenesis.

The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis

Hemiketal E2, a lipid autacoid, promotes angiogenesis by enhancing VEGFR2 activation and inducing endothelial cell tubulogenesis in vitro and in vivo, suggesting potential for antiangiogenic therapy.

The 5-LOX/COX-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis

Hemiketal E2, a metabolite of arachidonic acid, promotes angiogenesis and may be a valid anti-angiogenic candidate.

Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis

Antiplatelet agents affecting GPCR signaling may potentially restrain cancer metastasis by affecting platelet activation and driving metastatic signaling pathways in cancer cells.

Pharmacological antagonism of EP2 receptor does not modify basal cardiovascular and respiratory function, blood cell counts, and bone morphology in animal models.

EP2 antagonists do not cause adverse effects on cardiovascular and respiratory systems, blood counts, and bone structure in healthy rodents, paving the way for potential therapeutic applications.

Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development

Maternal fatty acid metabolism during pregnancy plays a crucial role in fetal brain development and placental development, with factors like obesity, diabetes, and dietary intakes impacting these processes.

Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions

The tumor microenvironment plays a crucial role in regulating tumor growth, progression, and metastasis, and novel immunotherapies targeting this environment are in clinical trials for various tumor entities.