P. S. Lacerda, Joyce Benzaquem Ribeiro, S. Leite
Apr 18, 2006
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron-asymmetry
Abstract
Herein, different microorganisms were tested in the enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate in aqueous medium for the preparation of ethyl (R)-2-hydroxy-4-phenylbutyrate, a key intermediate in the production of angiotensin converting enzyme (ACE) inhibitors. The use of Pichia angusta led to the (R)-enantiomer in 81% ee.